Nanofibers, usually defined as fibers with diameters on the nanoscale (1 – 1000 nm), have during the last decade received great attention both in the academia and industry. The large surface to volume ratio generates several interesting properties which are desirable for a great variety of applications. Although this type of material and its applications are still in their cradle, the industry and academia have already begun to explore its possibilities and significant advantages are made possible within already well-established industries.
Large specific surface area
Structures on the nanofiber scale have a large surface-to-volume ratio, which is very attractive in eg. sensor applications.
The networks are extremely lightweight, have pores of small sizes and interconnected pore structures.
Although small in size, the fibers give rise to interesting mechanical properties, especially when combined in composite materials.
Flexibility in functionalization
The fiber networks can easily be functionalized using a wide range of techniques.
What makes Cellevate unique?
What sets us apart from other providers offering similar solutions is our own unique technology that allows our solution to truly scalable, reproducible and incredibly flexible when it come to customization.
Cellevates nanofiber scaffolds for 3D cell culture are produced through our own patented technique. We have revised the standard electrospinning method used to create most of our competitions products and improved it with regard to scaffold parameter control (and consequently overall fiber quality) and batch-to-batch consistency. Finally, our unique technology allows us to solve the most pressing issue with nanomaterial production, throughput. While competing solutions produce nanofiber materials in the range of square decimeters per hour, Cellevates technology allows us to produce square meters per minute.
This allows us to tailor these materials with unparalleled precision, scalability and opportunities for customization.
Why customized solutions?
The extracellular matrices (ECM) around various tissues range from elastic (brain tissue) to inelastic (bone tissue). Stems cells sense the elasticity of the local microenvironment as a cue to differentiate into the corresponding tissue. The elasticity and topography of a biomimetic scaffold can be used to modulate cell phenotypes and tissue morphogenesis via mechanical transduction.
While it is nontrivial to tune all the various parameters for a given application — it can confer huge benefits in terms of performance and domain of applicability.
The ability to tune ECM morphology and elasticity creates a differentiated and proprietary advantage and can be used e.g. for phenotypic screening applications. What has traditionally been perceived to be a liability in terms of complexities versus spheroids and hydrogels we have reconceived as a defining advantage that leverages Cellevate’s core strengths and tacit knowledge base to create tailor made solutions that cannot be easily replicated.
Cellevates solution is easily adapted to your set-up, and is readily available in standard cell culture formats including but not limited to standard petri dishes, multiwell plates (4-, 6-, 12-, 24-, 48-, and 96-wells), inserts and chamber slides to make sure you find what you need. Finally, all our products are xeno-free unless specifically stated otherwise.
Are you ready?
Take the first step towards a tailor-made 3D in-vitro model of your own today.