In this case working for a major pharmaceutical company, Cellevate was tasked with helping improve the relevance of their in-vitro models in psychiatric disease research. Therefore, we offered to help create a unique model set out to developed a disease relevant cellular 3D model based on astrocytes and neurons generated from iPSCs.
After creating a broad understanding of the issues our customer had been experiencing, our technical team set out to create an evaluation platform that would address specific issues with a focus on 1. Physiological relevance 2. Specific readouts 3. Useability. Based on these criteria, several types of nanofibrous scaffolds were prepared and evaluated at the customer site in an initial round of testing.
After the first optimization experiments were concluded, the customer chose to proceed with the design they found best related to their needs.